
Cortical Evolution | Bilbao, Spain 2026
CAJAL CLUB | PAST MEETINGS | PAGE 15
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Cajal Club | Satellite Meeting | Bilbao, Spain
Cortical Evolution
The 2026 Cortical Evolution Conference was held in Bilbao, Spain, June 15–17, bringing together leading neuroscientists studying cortical development, evolution, and function. During the meeting, the Cajal Club presented its 2026 Pinckney J. Harman Memorial Lecture delivered by Professor Zoltán Molnár.
This conference brought together the best neuroscientists from Europe, the Americas and Africa to discuss the evolutionary origins and development of the mammalian cerebral cortex. The conference was organized by Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino and Stephen Noctor and consisted of faculty, trainees and researchers from around the world. It included established investigators who presented their work as well as posters and short talks from early career researchers.
The scientific program brought together established international experts from various fields of study including developmental neuroscience and evolutionary neuroscience. In addition to the faculty members, who are currently directing laboratories all over the world, trainees from different countries and research fields presented their research as posters as well as were selected to deliver short talks to introduce their work as emerging researchers. The topics covered by the presentations focused on current research on cortical evolution from the point of view of human brain development, cortical neurogenesis, and comparative neuroanatomy and cognition. Also, various evolutionary mechanisms that have influenced the structure and function of the mammalian brain were discussed. The goal of the scientific program of the conference was to present current knowledge on the evolution of the cerebral cortex and its implications for normal functions of the brain as well as for neurodegenerative diseases.
Pinckney J. Harman Memorial Lecture
Professor Zoltán Molnár, of the Department of Physiology, Anatomy and Genetics at the University of Oxford and Fellow of St John’s College, was selected as the 2026 recipient of the Pinckney J. Harman Memorial Lecture by the Board of the Cajal Club at the annual Society for Neuroscience conference.
The Pinckney J. Harman Memorial Lecture is a prestigious distinction awarded to leading neuroscientists . Since its establishment in 1951–52, when the first lecture was delivered by Rafael Lorente de Nó, the award has recognised many of the most eminent figures in the field. Professor Molnár is the second Hungarian scientist to deliver the lecture, following János Szentágothai in 1971–72, and the second lecturer from the University of Oxford, following Ray W. Guillery in 1997–98.
The 2026 lecture took place during the Cortical Evolution Conference in Bilbao, held from 15–17 June 2026 . Professor Nenad Sestan, President-Elect of the Cajal Club and Harvey and Kate Cushing Professor of Neuroscience at Yale School of Medicine, presented the certificate and introduced Professor Molnár’s lecture, entitled “Subcortical Plate: A Transient Structure with Lasting Impact on Evolution, Circuit Assembly and Cognitive Functions.”
Professor Nenad Šestan said: “Professor Molnár is an authority on the development and evolution of the mammalian cerebral cortex. His work has been especially influential in revealing the importance of transient developmental structures and early patterns of connectivity in shaping the cerebral cortex, including the role of subplate neurons and thalamocortical pathways.”
Professor Molnár expressed his gratitude to the members of the Cajal Club for this recognition and for the opportunity to deliver the memorial lecture.
Learn more about Zoltán Molnár
![]() Nenad Šestan and Zoltán MolnárCortical Evolution Conference, Bilbao, Spain | ![]() Nenad Šestan introduces Zoltán MolnárCortical Evolution Conference, Bilbao, Spain | ![]() Zoltán Molnár, the 2026 Pinckney J. Harman Memorial LectureCortical Evolution Conference, Bilbao, Spain | ![]() Professor Zoltán Molnár Delivers the 2026 Pinckney J. Harman Memorial LectureCortical Evolution Conference, Bilbao, Spain | ![]() Nenad Šestan and Zoltán MolnárCortical Evolution Conference, Bilbao, Spain | ![]() Stephen Noctor, Fernando García-Moreno, Veronica Martinez-Cerdeno, and Zoltán MolnárCortical Evolution Conference, Bilbao, Spain |
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![]() Xuyu QianCortical Evolution Conference, Bilbao, Spain | ![]() Vizcaya BridgeBilbao, Spain | ![]() Guggenheim Museum BilbaoBilbao, Spain | ![]() Cajal Club Dinner: Chiaki Ohtaka-Maruyama and Leah KrubitzerCortical Evolution Conference, Bilbao, Spain | ![]() Cajal Club Dinner: Zoltán Molnár, Chiaki Ohtaka-Maruyama, Leah Krubitzer, Nenad Šestan, Arnold KriegCortical Evolution Conference, Bilbao, Spain | ![]() Cajal Club Dinner Leah Krubitzer toasting the groupCortical Evolution Conference, Bilbao, Spain |
![]() Cajal Club Dinner: Nenad Šestan toasting with Zoltán Molnár, Chiaki Ohtaka-Maruyama, Leah Krubitzer,Cortical Evolution Conference, Bilbao, Spain | ![]() Cajal Club Dinner: Luis Puelles, Fernando García-Moreno, Veronica Martinez-CerdenoCortical Evolution Conference, Bilbao, Spain | ![]() Bilbao, Spain | ![]() Mount Artxanda ViewpointBilbao, Spain | ![]() Bilbao, Spain | ![]() Arnold Kriegstein Cajal Club DiCortical Evolution Conference, Bilbao, Spain |
![]() Luis PuellesCortical Evolution Conference, Bilbao, Spain | ![]() Opera HouseBilbao, Spain | ![]() Bizkaia Aretoa Conference Center (foreground), Torre Iberdrola (background)Bilbao, Spain | ![]() Closing Conference Dinner: Christine Charvet,Xuyu Qian, Leah Krubitzer, Flora Vaccarino, Paul MangerCortical Evolution Conference, Bilbao, Spain | ![]() Conference closing dinner: Estela Maris Munoz, Richa Verma, Zoltan Molnar, Christine Charvet, Leah KCortical Evolution Conference, Bilbao, Spain | ![]() Closing Conference Dinner: Xuyu Qian, Estela Maris Munoz, Richa Verma, Zoltan Molnar, Christine CharCortical Evolution Conference, Bilbao, Spain |
![]() Closing Conference Dinner: Xuyu Qian, Estela Maris Munoz, Richa Verma, Zoltan Molnar, Christine CharCortical Evolution Conference, Bilbao, Spain | ![]() Conference closing dinner: Emiliano Brunner, Lucia Del Valle AntonCortical Evolution Conference, Bilbao, Spain | ![]() Conference closing dinner: Suzana Herculano-HouzelCortical Evolution Conference, Bilbao, Spain | ![]() Conference Closing DinnerCortical Evolution Conference, Bilbao, Spain | ![]() Conference closing dinner: Chiaki Ohtaka-Maruyama, Fernando García-Moreno, Boyan Bonev, Silvia CappeCortical Evolution Conference, Bilbao, Spain | ![]() Conference closing dinner: Boyan Bonev, Silvia Cappello, Victor BorrellCortical Evolution Conference, Bilbao, Spain |
![]() Conference closing dinner: Chiaki Ohtaka-Maruyama, Fernando García-Moreno, Boyan BonevCortical Evolution Conference, Bilbao, Spain | ![]() Palace of the Provincial CouncilBilbao, Spain | ![]() Guggenheim Museum BilbaoBilbao, Spain | ![]() Guggenheim Museum BilbaoBilbao, Spain |
Cortical Development Conference 2025 | Session Summary
Session 1: Cortical Evolution
Chair: Paul Manger
Speakers:
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Zoltán Molnár–Pinckney J. Harman Memorial Lecture: Subcortical plate: A Transient Structure with Lasting Impact on Evolution, Circuit Assembly and Cognitive Functions
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Catherine Crockford–Vocal utterance complexity in chimpanzees has implications for language and brain evolution theories
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Arnold Kriegstein–What human brain development can teach us about disease, evolution, and human speech
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Leah Krubitzer–Cortical areas involved in motor control of the limbs: Plasticity within and across lifetimes
Session 2: Specification and Early Development
Chair: Arnold Kriegstein
Speakers:
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Victor Borrell–Evolutionary convergence and divergence of cortical neurogenesis
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Flora Vaccarino–Reconstructing human development with induced pluripotent cells and somatic mutations
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Madeline Lancaster–Slow and steady wins the race: Delayed transition timing enables human-specific neural expansion
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Nenad Šestan–Development and evolution of cognitive networks: Exploring what makes us human
Short Talks:
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Jonathan W.C. Lim – Nuclear factor one transcription factors regulate radial glia differentiation during early cortical development
Session 3: Disease and Therapeutics
Chair: Nenad Šestan
Speakers:
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Fenna Krienen
Spatial patterning of transcriptional and regulatory programs in the primate brain -
Oier Pastor-Alonso
Organization & Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus -
Boyan Bonev
Epigenetic Regulation of Human Brain Evolution -
Lucia Del-Valle-Anton
From development to regeneration: Single-cell multiome analysis of neural progenitors in the salamander pallium -
Silvia Cappello
Post-translational Dynamics in Brain Evolution
Short Talks:
Chair: Victor Borrell
Speakers:
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Chiaki Ohtaka-Maruyama
Dual evolutionary origins of mammalian subplate neurons -
Hiroshi Kawasaki
Formation, evolution and functional significance of cortical folds -
Mark Noble
A functional single-cell atlas of Neanderthal variants in ancestralized human cerebral organoids
Session 4: Circuit Development
Chair: Flora Vaccarino
Speakers:
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Suzana Herculano-Houzel
Evolution of brain and body size in endotherms explained by self-limiting growth -
Luis Puelles
Advances on the mouse limbic cortical ring (mesocortex): the pattern of thalamic connections -
Paul Manger
Thalamic and cortical volumetric relationships: does thalamotype reveal corticotype in mammals? -
Christine Charvet
Translating Time from multiple scales -
Alexandra de Sousa
Energetic Constraints on Brain Organization
Short Talks:
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Chair: Fernando García Moreno
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Emily Casanova
Gene family expansions and their roles in early stages of nervous system evolution -
Sara Jiménez
Sauropsid embryonic brains lack the mammalian temporal transcriptional program -
Eirene Markenscoff Papadimitriou
Evolution of human cortical development via transposable element exaptation into novel cis-regulatory elements -
Richa Verma
Cell to volume characterization of the fetal Hippocampal Formation

















































